Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6015731 | Epilepsy Research | 2013 | 9 Pages |
Abstract
AEA and WIN both reduced absence seizures independently from the brain focal site of infusion while, conversely, rimonabant increased absence seizures but only when focally administered to the ventroposteromedial thalamic nucleus (VPM). These results, together with previous reports, support therapeutic potential for endocannabinoid system modulators in absence epilepsy and highlight that attenuated endocannabinergic function may contribute to the generation and maintenance of seizures. Furthermore, the entire cortico-thalamic network responds to cannabinoid treatment, indicating that in all areas considered, CB receptor activation inhibits the pathological synchronization that subserves absence seizures. In conclusion, our result might be useful for the identification of future drug therapies in absence epilepsy.
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Authors
Rita Citraro, Emilio Russo, Richard T. Ngomba, Ferdinando Nicoletti, Francesca Scicchitano, Benjamin J. Whalley, Antonio Calignano, Giovambattista De Sarro,