Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Article ID	Journal	Published Year	Pages	File Type
6015838	Epilepsy Research	2013	14 Pages	PDF

Abstract

The comparative in vivo pharmacokinetic data obtained in the present work might be usefully applied in the context of discovery of new antiepileptic drugs that are derivatives of CBZ.

Keywords

MRT apparent terminal elimination half-life CBZ-E TD50 NSB OXC ESL tmax ED50 AEDs ppb ADME Cbz Cmax LOQ AUC DMSO t1/2 non-specific binding Plasma protein binding internal standard Eslicarbazepine acetate Ultrafiltration Oxcarbazepine Maximal electroshock seizure antiepileptic drugs In silico CNS Dimethyl sulfoxide Blood–brain barrier BBB central nervous system Pharmacokinetics absorption distribution metabolism and excretion limit of quantification MeS Brain Mean residence time Carbamazepine-10,11-epoxide carbamazepine high performance liquid chromatography HPLC

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Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Authors

Ana Fortuna, Gilberto Alves, PatrÃcio Soares-da-Silva, AmÃlcar FalcÃ£o,