Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6015843 | Epilepsy Research | 2013 | 7 Pages |
Abstract
Our findings in humans are in agreement with those found in animal models, supporting oxidative stress as a relevant mechanism also in human epilepsy. The concurrent increase in catalase and decrease in GPx, together with unchanged SOD levels, suggests catalase as the main antioxidant enzyme in human epileptic neocortex. The substantial increase in the levels of O2â and 8-oxo-dG in epileptic patients supports a connection between chronic seizures and ROS-mediated neural damage.
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Authors
Jordi Rumià , Frederic Marmol, Juan Sanchez, José Giménez-Crouseilles, Mar Carreño, Núria Bargalló, Teresa Boget, Luis Pintor, Xavier Setoain, Antonio Donaire, Guillermo T. Saez, Teresa Ribalta, Enric Ferrer, Pere Puig-Parellada,