Identifying SNP targeted pathways in partial epilepsies with genome-wide association study data

► Traditional genome-wide association studies cannot find strong associations. ► We consider functional effect of single nucleotide polymorphism, networks, pathways. ► We show that the identified pathways elucidate the mechanisms underlying epilepsy. ► We show that different factors affect distinct parts of pathways for disease development. ► We dissect leading molecular pathways that cannot be found with traditional analyses.