| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6016011 | Epilepsy Research | 2013 | 4 Pages |
Abstract
This is the first investigation of MMPs in children with febrile seizures. In a prospective, cross sectional study, serum levels of matrix metalloproteinases (MMP8/9), tissue inhibitor of metalloproteinases (TIMP1/2), of children with FS (n = 13), children with febrile infection (FI, n = 13) and children with unprovoked generalized seizures (US, n = 11) were compared. Neither provoked nor unprovoked seizures in FS and US seem to elevate levels of MMPs or TIMPs, whereas in case of febrile infection blood level of MMP8 was significant elevated. Seizures in general might have no influence on this distinctive inflammatory process or even might have suppressive impact.
Keywords
ZnSOXCIL-6VPAESMLTGLEVMMPZonisamideEthosuximideElectroencephalogramOxcarbazepineinterleukin-6febrile seizurestumour necrosis factor-alphaCNSTIMPCerebral Spinal FluidCytokineproinflammatory cytokinescentral nervous systemTNF-αPhenobarbitalLamotriginelevetiracetammatrix-metalloproteinasematrix metalloproteinaseCSFTissue inhibitor of metalloproteinaseEEGValproic acidC-reactive proteinCRPChildren
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Authors
Edda Haberlandt, Markus Rauchenzauner, Maike Morass, Petra Wondrak, Sabine Scholl- Bürgi, Kevin Rostásy, Daniela Karall,