| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6016121 | Epilepsy Research | 2012 | 5 Pages |
Abstract
We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6Â h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4â/â compared to AQP4+/+ mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.
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Authors
Darrin J. Lee, Mariam Amini, Mark J. Hamamura, Mike S. Hsu, Marcus M. Seldin, Orhan Nalcioglu, Devin K. Binder,