Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6016243 | Epilepsy Research | 2012 | 6 Pages |
Abstract
Changes seen when inducer-treated patients are converted to TPM closely mimic those seen when inducer-treated patients are converted to lamotrigine or levetiracetam. These findings provide evidence that CYP450 induction elevates CRP and serum lipids, including LDL particles, and that these effects are reversible upon deinduction. Low-dose TPM appears not to induce the enzymes involved in cholesterol synthesis.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Scott Mintzer, Christopher T. Skidmore, Sara J. Rankin, Inna Chervoneva, Edward Pequinot, David M. Capuzzi, Michael R. Sperling,