| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6016320 | Epilepsy Research | 2009 | 4 Pages |
Abstract
SummaryHere we studied the long-term effects of neonatal seizures on inhibitory synaptic transmission in somatosensory cortex. We found that recurrent flurothyl-induced seizures result in a marked reduction in amplitude of spontaneous inhibitory postsynaptic currents (IPSCs) and increases of miniature IPSCs interevent intervals. These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Elena Isaeva, Dmytro Isaev, Rustem Khazipov, Gregory L. Holmes,