Anti-glycan antibodies halt axon regeneration in a model of Guillain BarrÃ¨ Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2

Article ID	Journal	Published Year	Pages	File Type
6017070	Experimental Neurology	2016	31 Pages	PDF

Keywords

DRG Anti-glycan antibodies DRGN RhoA GTPase Limk1 TUJ-1 Y-27632 MIA CRMP-2 p75NTR Ganglioside MTS GBS MAG mAbs IgG dorsal root ganglion Förster resonance energy transfer FRET immunoglobulin G Axon regeneration Nerve repair Intraperitoneally Guillain Barré syndrome Peripheral nerve Growth cone Microtubules dorsal root ganglion neurons Monoclonal antibodies Rho-associated kinase Myelin-associated glycoprotein Rock

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Life Sciences Neuroscience Neurology

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Anti-glycan antibodies halt axon regeneration in a model of Guillain BarrÃ¨ Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2

Authors

Victoria Rozés Salvador, Florencia Heredia, Andrés Berardo, Anabela Palandri, Jose Wojnacki, Ana L. Vivinetto, Kazim A. Sheikh, Alfredo Caceres, Pablo H.H. Lopez,