A blinded, randomized study of l-arginine in small clot embolized rabbits

This study demonstrates that the l-arginine component of the tPA vehicle does not contribute to the reproducible clinical improvement observed following tPA administration in rabbits. Moreover, the administration of l-arginine was not an effective method to promote behavioral recovery following embolic strokes in the stringent rabbit small clot stroke model, nor did l-arginine exacerbate behavioral deficits or intracerebral hemorrhage in embolized rabbits.