| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6017871 | Experimental Neurology | 2014 | 12 Pages |
Abstract
HO-1 promotes mitochondrial damage and CA biogenesis in astrocyte cultures and in the intact aging brain. CA formation is enhanced in the MCI hippocampus and thus occurs relatively early in the pathogenesis of AD. Glial HO-1 suppression may attenuate bioenergetic failure and slow disease progression in AD and other neurodegenerative conditions featuring accelerated accumulation of CA.
Keywords
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Wei Song, Hillel Zukor, Adrienne Liberman, Sagi Kaduri, Zoe Arvanitakis, David A. Bennett, Hyman M. Schipper,