Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and Aβ1-42 gene transfer models

► p-Tau leads to inflammation and increased levels of ADAM-10/17. ► Seeding for p-Tau with lentiviral Aβ1-42 produces neuro-inflammation. ► Microglial activity is associated with CX3CL1 and p-Tau. ► Autophagic changes are associated with neuro-inflammation. ► p-Tau accumulates within autophagic vacuoles not lysosomes.