Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6018157 | Experimental Neurology | 2013 | 6 Pages |
Abstract
Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adenylyl cyclase (AC) assays showed lower basal and pituitary adenylate cyclase-activating peptide-evoked AC activities in the brainstem of AC6-null mice, indicating that AC6 is a prominent AC isozyme in the brainstem. Furthermore, two independent lines of AC6-null mice exhibited a much higher SND, recorded from splanchnic sympathetic nerves of neonatal brainstem-spinal cord preparations, than wildtype mice. An assay of urine noradrenaline confirmed this observation. Collectively, AC6 plays a critical role in the regulation of sympathetic tone.
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Authors
Chen-Li Chien, Meng-Syuan Lin, Hsing-Lin Lai, Yu-Shuo Wu, Ching-Pang Chang, Huei-Mei Chen, Chen Chang, Chun-Kuei Su, Yijuang Chern,