Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes

► Polyglutamine expansion on htt reduces AP2-membrane interaction in the mice striatum. ► Mutation in htt also alters AP2-membrane interaction in striatal cells. ► The mutant of htt loses interaction with AP2. ► Clathrin-mediated endocytosis is affected in striatal cells with mutated htt. ► Mutation on htt increases vulnerability of striatal cells to excitotoxicity by QA.