| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018199 | Experimental Neurology | 2013 | 10 Pages |
Abstract
⺠PBDEs share many physiochemical properties as the dopaminergic neurotoxicant, PCBs. ⺠PBDEs are previously shown to inhibit vesicular dynamics in dopamine system. ⺠PBDEs disrupt the nigrostriatal dopamine system, in vitro and in vivo. ⺠Disruption is exacerbated in transgenic mice with a 95% reduction in VMAT2. ⺠These are the first data demonstrating a role of PBDEs in dopamine neurotoxicity.
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Authors
Joshua M. Bradner, Tiffany A. Suragh, W. Wyatt Wilson, Carlos R. Lazo, Kristen A. Stout, Hye Mi Kim, Min Z. Wang, Douglas I. Walker, Kurt D. Pennell, Jason R. Richardson, Gary W. Miller, W. Michael Caudle,