Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy

Article ID	Journal	Published Year	Pages	File Type
6018296	Experimental Neurology	2013	7 Pages	PDF

Abstract

âº Endoplasmic reticulum stress contributes to prediabetic neuropathy. âº Trimethylamine oxide abrogates sciatic nerve ER stress in Zucker fatty rats. âº Trimethylamine oxide alleviates prediabetic neuropathy in Zucker fatty rats. âº Salubrinal improves glucose tolerance in high-fat diet fed mice. âº Salubrinal alleviates peripheral nerve dysfunction in high-fat diet fed mice.

Keywords

Salubrinal Eukaryotic initiation factor-2α Endoplasmic reticulum stress streptozotocin Trimethylamine oxide Sensory nerve conduction velocity motor nerve conduction velocity diabetic peripheral neuropathy Unfolded protein response