| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018301 | Experimental Neurology | 2013 | 14 Pages |
Abstract
⺠E3 ligase parkin was overexpressed in the nigrostriatal dopamine system in the rat. ⺠Parkin overexpression decreased methamphetamine toxicity to striatal terminals. ⺠Parkin protection did not involve upregulation of the 20S proteasome. ⺠Parkin protection did not involve decreasing methamphetamine-induced hyperthermia.
Keywords
VmaxSuc-LLVY-AMCAAVAmCSNCDABSALStriatumSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresissubstantia nigra pars compactatyrosine hydroxylaseCNSDopaminediaminobenzidineSalinemaximal velocityToxicitycentral nervous systemanterior–posteriorMETHMethamphetamineNeuroprotectionMedio-lateralventralAdeno-associated virusParkin
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Authors
Bin Liu, Roberta Traini, Bryan Killinger, Bernard Schneider, Anna Moszczynska,