| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018321 | Experimental Neurology | 2013 | 9 Pages |
Abstract
⺠Rho-kinase activity was enhanced in the sciatic nerves of diabetic rats. ⺠Fasudil exerted beneficial effects on the delayed nerve conduction velocity. ⺠The enhanced Rho-kinase activity induced decrease in adhesion molecules. ⺠E-cadherin and p120-catenin were key adhesion molecules affected by Rho-kinase. ⺠Disorganized adhesion structures could relate to mechanisms of diabetic neuropathy.
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Authors
Yasushi Kanazawa, Junko Takahashi-Fujigasaki, Sho Ishizawa, Naoko Takabayashi, Kumiko Ishibashi, Keiichiro Matoba, Daiji Kawanami, Tamotsu Yokota, Naoko Tajima, Kazunori Utsunomiya,