Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6018336 | Experimental Neurology | 2013 | 10 Pages |
Abstract
⺠Mice lacking the Engrailed 2 gene are a model for autism spectrum disorders. ⺠We show a loss of hippocampal and cortical GABAergic interneurons in En2 null mice. ⺠We propose a link between altered function of En2, GABAergic dysfunction and autism.
Keywords
vasointestinal peptideHomeobox transcription factorRT-PCRVGLUTGADEngrailed-2VIPEn2NPYVGATCCKglutamic acid decarboxylaseSOMNeurodevelopmental disorderautism spectrum disordersγ-aminobutyric acidInterneuronInhibitionvesicular GABA transportervesicular glutamate transporterSomatostatindentate gyrusASDreverse transcription polymerase chain reactionParvalbuminSingle-nucleotide polymorphismSNPCalbGABANeuropeptide Y
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Authors
Paola Sgadò, Sacha Genovesi, Anna Kalinovsky, Giulia Zunino, Francesca Macchi, Manuela Allegra, Elisa Murenu, Giovanni Provenzano, Prem Prakash Tripathi, Simona Casarosa, Alexandra L. Joyner, Yuri Bozzi,