Mindin is a critical mediator of ischemic brain injury in an experimental stroke model

Article ID	Journal	Published Year	Pages	File Type
6018339	Experimental Neurology	2013	11 Pages	PDF

Abstract

âº Ischemic brain injury is attenuated in mindin knockout mice, and aggravated in mindin transgenic mice. âº Mindin mediates neuronal apoptosis and inflammation in an experimental stroke model. âº Akt/eNOS signaling is enhanced in the ischemic brain of mindin knockout mice.

Keywords

ornithine carbamyl transferase CBF eNOS ECM MCP-1 TTC GSK3 ICAM-1 mTOR tPA PDGF TMCAO MCA PBS VCAM-1 MMP NF-κB TNF 2,3,5-triphenyl-2H-tetrazolium chloride TLRs Akt inflammation transient middle cerebral artery occlusion Oct Ischemia interleukin cerebral blood flow Apoptosis endothelial nitric oxide synthase Stroke middle cerebral artery platelet-derived growth factor tumor necrosis factor nuclear factor kappa B tissue plasminogen activator Extracellular matrix matrix metalloproteinase phosphate buffer solution intercellular adhesion molecule-1 vascular cell adhesion molecule-1 mammalian target of rapamycin polymerase chain reaction PCR monocyte chemoattractant protein-1 protein kinase B glycogen synthase kinase 3 Toll-like receptors