| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018344 | Experimental Neurology | 2013 | 6 Pages |
Abstract
⺠In the current study we assessed the cardiovascular phenotype of tg MSA mice. ⺠The α-syn-overexpressing MSA mice had decreased HRV. ⺠We detected depletion of cholinergic neurons in the nucleus ambiguus in MSA mice. ⺠The reduced HRV might be associated with neurodegeneration in the nucleus ambiguus.
Keywords
AVPGCISNDMSA-pMSA-Cα-SynOPCARMSSDPLPMSAOlivopontocerebellar atrophyMultiple system atrophyarginine-vasopressinAlpha-synucleinelectrocardiogramECGSPECTTransgenicMagnetic resonancesingle-photon emission computed tomographyPositron emission tomographytyrosine hydroxylaseStriatonigral degenerationAutonomic failurehigh frequencylow frequencyTransgenic animal modelheart rate variabilitywild typePETChATcholine-acetyltransferase
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Authors
Daniela Kuzdas, Sylvia Stemberger, Stefano Gaburro, Nadia Stefanova, Nicolas Singewald, Gregor K. Wenning,