Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia

Article ID	Journal	Published Year	Pages	File Type
6018422	Experimental Neurology	2013	8 Pages	PDF

Abstract

âº NBO combined with minocycline showed greater neuroprotection in ischemic stroke. âº The combination therapy led to greater reduction in hemispheric swelling. âº Inhibition on MMP-2/9, caspases and AIF accounts for the greater protection.

Keywords

FDA Normobaric hyperoxia ICA ECA NBO MMP MCAO TTC DMSO AIF middle cerebral artery occlusion Infarction Oxygen Food and Drug Administration BBB blood brain barrier Stroke external carotid artery internal carotid artery apoptosis-inducing factor matrix metalloproteinase Minocycline