| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018425 | Experimental Neurology | 2013 | 16 Pages |
Abstract
⺠We present a slice preparation of bilateral hippocampi connected by a fiber tract. ⺠Stimulation with one fiber-tract electrode reduces bilateral hippocampal seizures. ⺠Seizure reduction does not involve depolarization block, LTD, or GABAA receptors. ⺠Post-stimulation seizure reduction is observed and requires connected hippocampi. ⺠It is correlated with an increase in low-frequency interictal bursting.
Keywords
HFSfimbria–fornixsAHPUPOvHCLFSMTLEDBSLuxol Fast BlueLFBIACUCDHCaCSFANTPDS4-AP4-aminopyridineSprague–Dawleyevoked potentialEpilepsyElectrical stimulationdeep brain stimulationhigh frequency stimulationlow frequency stimulationParoxysmal depolarizing shiftInstitutional Animal Care and Use CommitteeBMImesial temporal lobe epilepsyEntorhinal cortexartificial cerebral spinal fluidbicuculline methiodideUnstable periodic orbitAnterior nucleus of thalamusaction potentialSeizure reduction
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Authors
Sheela Toprani, Dominique M. Durand,