| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018441 | Experimental Neurology | 2013 | 16 Pages |
Abstract
⺠MRI analysis of whole brain and specific regions was performed in two EAE models. ⺠Multiple brain regions are affected in chronic and in relapsing-remitting EAE. ⺠Macromolecular loss and structural CNS damage are typical mainly to chronic EAE. ⺠Glatiramer acetate (GA) treatment improved the MRI parameters: T2, MTR and ADC. ⺠MRI restoration and oligodendrocyte proliferation indicate neuroprotection by GA.
Keywords
Glatiramer acetate (GA)MOGVBAMTRPLPDTIEAEProteolipid proteinExperimental autoimmune encephalomyelitis (EAE)experimental autoimmune encephalomyelitisMagnetic Resonance Imaging (MRI)diffusion tensor imagingDiffusion tensor imaging (DTI)CNScentral nervous systemNeuroprotectionMultiple sclerosis (MS)Multiple sclerosismagnetization transfer ratioglatiramer acetate
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Authors
Rina Aharoni, Efrat Sasson, Tamar Blumenfeld-Katzir, Raya Eilam, Michael Sela, Yaniv Assaf, Ruth Arnon,