Novel Approach to Benzimidazoles Using Fe3O4 Nanoparticles as a Magnetically Recoverable Catalyst

Magnetically recoverable Fe3O4 nanoparticles have been synthesized as a catalyst for the cyclocondensation of 1,2-phenylenediamines with orthoesters under solvent-free conditions. Catalyst loadings can be as low as 1 mol% to give high yields of the corresponding benzimidazole derivative at 80 °C. This green method offers significant advantages in terms of its simplicity, low catalyst loadings, high product yields, and non-toxic nature. The Fe3O4 nanoparticles were characterized by X-ray diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy.

Graphical abstractThis manuscript describes an eco-friendly method for the synthesis of some benzimidazoles using Fe3O4 nanoparticles. This method has some advantages, such as high yield of product, short reaction times, and avoidance of organic solvents.Figure optionsDownload full-size imageDownload as PowerPoint slide