| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018535 | Experimental Neurology | 2012 | 17 Pages |
Abstract
⺠Mouse model of PD that overexpresses alpha synuclein show microglial activation. ⺠Microglial activation occurs early and is progressive with age. ⺠Microglial activation is confined to the striatum and substantia nigra. ⺠The pro-inflammatory cytokine TNF-alpha is increased with microglia activation. ⺠Toll-like receptors are increased in substantia nigra and may activate microglia.
Keywords
TLRIL-1βPFACRBTBSSTRPBSCTXIba-1Alpha-synucleinStriatuminflammationInterleukin-1 betaSPECTOverexpressionParkinson's diseaseTransforming Growth Factor BetaTransgenicTris buffered salinesubstantia nigraNeurodegenerationtumor necrosis factor alphatyrosine hydroxylaseToll-like receptorintraperitonealDopaminergicCytokinesTNF-αPhosphate buffered salinecerebral cortexCerebellumnot determinedionized calcium binding adaptor molecule 1Microglia
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Melanie B. Watson, Franziska Richter, Soo Kyung Lee, Lauryn Gabby, Jennifer Wu, Eliezer Masliah, Rita B. Effros, Marie-Françoise Chesselet,