| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018564 | Experimental Neurology | 2012 | 7 Pages |
Abstract
⺠We investigated the effect of limited proteolytic cleavage on tau oligomer formation. ⺠MMP-3/-9, which are elevated in AD and PSP, generate specific tau cleavage products. ⺠Tau fragments were characterized by SDS-PAGE and mass spectroscopy. ⺠Limited cleavage by MMP-9 promotes tau oligomer formation detected by FCS and SIFT. ⺠Extracellular proteases such as MMP-9 may thus contribute to tau pathology.
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Authors
G. Nübling, J. Levin, B. Bader, L. Israel, K. Bötzel, S. Lorenzl, A. Giese,