Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis

► Maternal TH deficiency impairs neuronal differentiation in developing neocortex. ► Maternal TH deferentially affects direct and indirect neurogenesis. ► Maternal TH deficiency down-regulates the indirect neurogenesis. ► Rate of neurogenesis reduces under MTHD in developing neocortex. ► Neuronal progenitors are responsive to TH.