| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018588 | Experimental Neurology | 2012 | 8 Pages |
Abstract
⺠Cortical spreading depression (CSD) is thought to cause migraine aura symptoms. ⺠Administration of l-kynurenine suppresses KCl-induced CSD in rat. ⺠This effect is probably due to an increase of kynurenic acid levels in the cortex. ⺠l-kynurenine-induced CSD inhibition is more pronounced in female than in male rats. ⺠These results open new perspectives for preventive migraine treatment.
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Authors
Virginie Chauvel, Eniko Vamos, Arpad Pardutz, Laszlo Vecsei, Jean Schoenen, Sylvie Multon,