| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018592 | Experimental Neurology | 2012 | 10 Pages |
Abstract
⺠Circadian rhythms are altered in Alzheimer's disease (AD) patients. ⺠Circadian rhythms and clock genes were tested in an AD model, APPxPS1 knock-in mice. ⺠Clock genes and sleep-wake but not activity rhythms were changed in APPxPS1 mice. ⺠APPxPS1 and wild-type (CD-1/129) mice exhibited significant daytime activity. ⺠Age-related decreases in activity and sleep were observed in both genotypes.
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Authors
Marilyn J. Duncan, J. Tyler Smith, Kathleen M. Franklin, Tina L. Beckett, M. Paul Murphy, Daret K. St. Clair, Kevin D. Donohue, Martin Striz, Bruce F. O'Hara,