| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018602 | Experimental Neurology | 2012 | 12 Pages |
Abstract
⺠Intrinsic hyperexcitability is observed in NPCs and neurons obtained from wobbler mouse NPCs. ⺠Na current density and spike generation increase during in vitro differentiation of NPCs. ⺠NPCs from the SVZ provide an in vitro model to study the discharge properties of cortical neurons. ⺠NPCs may provide an “in vitro” model to study cortical hyperexcitability of ALS patients. ⺠NPCs may help to identify pharmacological tools to counteract neurodegeneration in ALS.
Keywords
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Francesca DiFebo, Daniela Curti, Francesca Botti, Gerardo Biella, Paolo Bigini, Tiziana Mennini, Mauro Toselli,