Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6018607 | Experimental Neurology | 2012 | 9 Pages |
Abstract
⺠WIN 55,212-2 pre-treatment decreases stress-induced norepinephrine release in frontal cortex. ⺠Acute WIN 55,212-2 exposure desensitizes cortical α2-adrenergic receptors (α2-AR). ⺠Cannabinoid modulation of adrenergic receptors is stress-dependent. ⺠Stress prevented the desensitization of α2-ARs produced by a history of cannabinoid exposure.
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Authors
B.A.S. Reyes, P. Szot, C. Sikkema, A.M. Cathel, L.G. Kirby, E.J. Van Bockstaele,