Influence of corticostriatal Î´-opioid receptors on abnormal involuntary movements induced by L-DOPA in hemiparkinsonian rats

Article ID	Journal	Published Year	Pages	File Type
6018609	Experimental Neurology	2012	12 Pages	PDF

Abstract

âº Î´-Opioid receptors and l-DOPA-induced dyskinesias in a model of Parkinson's disease. âº DPDPE, a Î´-opioid agonist, increased the expression of l-DOPA-induced dyskinesias. âº Naltrindole, a Î´-opioid antagonist reduced the number of l-DOPA-induced dyskinesias. âº A cortical lesion decreased the number of Î´-opioid receptors. âº A cortical lesion prevented the stimulant effect of DPDPE on dyskinesias.

Keywords

6-OHDA D/V DPDPE M/L MFB N-methyl-d-aspartate NMDA LID A/P l-DOPA EDTA Ethylenediaminetetraacetic acid AIMS medial forebrain bundle Parkinson's disease abnormal involuntary movements dyskinesia L-DOPA-induced dyskinesia δ-Opioid receptors