| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018617 | Experimental Neurology | 2012 | 12 Pages |
Abstract
⺠hCAST overexpression in transgenic mice effectively reduced protease activity. ⺠Brain injury-induced spectrin proteolysis was blunted in hCAST transgenic mice. ⺠hCAST overexpression partially protected the hippocampus but not cortex after TBI. ⺠Motor function was improved in brain-injured mice overexpressing hCAST. ⺠In mice with TBI, object recognition memory was improved by hCAST overexpression.
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Authors
Kathleen M. Schoch, Heather N. Evans, Jennifer M. Brelsfoard, Sindhu K. Madathil, Jiro Takano, Takaomi C. Saido, Kathryn E. Saatman,