| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018674 | Experimental Neurology | 2012 | 11 Pages |
Abstract
⺠Embryonic stem cells (ESCs) were transplanted to the damaged rat auditory nerve. ⺠Good survival and neuronal differentiation of the ESCs was observed. ⺠Brain derived neurotrophic factor (BDNF) in bioactive gel increased ESC survival. ⺠BDNF in bioactive gel improved the neuronal differentiation rate of the ESCs. ⺠Chondroitinase ABC in bioactive gel facilitated migration.
Keywords
FBSβ-BuTxβ-BungarotoxinTuj1IKVAVE13NT-3CSPGGAGChABCSGNABRPFADAPIPBSROIGFP4′,6-diamidino-2-phenylindoleBDNFEDTAEthylenediaminetetraacetic acidscala tympaniESCCNSbrain stemfetal bovine serumStem cellEmbryonic stem cellcentral nervous systemperipheral nervous systembrain derived neurotrophic factorAuditory nerveCerebrospinal fluidCSFPhosphate-buffered salineIAMTransitional zoneregion of interestNeurotrophin 3spiral ganglion neuronCochlear Nucleusparaformaldehydeauditory brainstem responsegreen fluorescent proteinPeptide amphiphileCell transplantationPNSCochlear implantchondroitinase ABCChondroitinaseGlycosaminoglycanInternal auditory meatus
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Authors
Björn Palmgren, Yu Jiao, Ekaterina Novozhilova, Samuel I. Stupp, Petri Olivius,