| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018699 | Experimental Neurology | 2011 | 10 Pages |
Abstract
⺠Calcium sensors STIM1 and STIM2 are present in neurons and astrocytes. ⺠Inhibition of SOCE reduces steady-state calcium in neurons but not in astrocytes. ⺠Inhibition of SOCE dampens and synchronizes network activity in multi-electrode arrays. ⺠STIM1 and STIM2 are increased in brains of chronic epileptic rodents. ⺠Inhibition of SOCE in chronic epileptic hippocampal slices rhythmizes epileptic bursts.
Keywords
RIPATRPCThapsigarginHBSSPFAPDLHprtaCSFSTIM1GAPDHSOCEIP32-aminoethoxydiphenyl borateFCS2-APBNMDAN-methyl-d-aspartateEGTAPBS-TSTIMMEFCTRLGFAPFAMfluorescein amiditeSTIM2FBSDMEMICRACPBSMEAIP3R5-carboxytetramethylrhodamineDulbecco's modified Eagle Mediuminositol 1,4,5-trisphosphatemulti-electrode arrayethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acidkainic acidradioimmunoprecipitation assay bufferstatus epilepticusEpilepsyTamraanalysis of varianceANOVAfetal bovine serumfetal calf serumSOCendoplasmic reticulumdentate gyrusPhosphate buffered salineNetwork activityartificial cerebrospinal fluidHanks' balanced salt solutionmouse embryonic fibroblaststromal interaction moleculeknock outwild typehypoxanthine phosphoribosyltransferaseStore-operated calcium entryparaformaldehydeGlial fibrillary acidic proteinPoly-d-lysineStore-operated channelsControlglyceraldehyde-3-phosphate dehydrogenaseIP3 receptor
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Authors
Julius A. Steinbeck, Nadine Henke, Jessica Opatz, Joanna Gruszczynska-Biegala, Lars Schneider, Stephan Theiss, Nadine Hamacher, Barbara Steinfarz, Stefan Golz, Oliver Brüstle, Jacek Kuznicki, Axel Methner,