Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter

Article ID	Journal	Published Year	Pages	File Type
6018708	Experimental Neurology	2011	6 Pages	PDF

Abstract

âº Neurofilaments are phosphorylated âº Protein phosphorylation competes with the free proton binding capacity âº Magnetisation transfer depends on magnetisation exchange between macromolecular bound and free protons âº In multiple sclerosis the phosphorylation status of neurofilaments is changed in otherwise normal appearing axons âº In vivo assessment of early axonal pathology is possible using magnetisation transfer

Keywords

BSP enzyme linked immunoabsorbent assay brain-specific proteins Magnetisation transfer ratio Neurofilament heavy chain SAPK MTR EDSS NFH IQR CTRL CDP Axonal injury MRI Biomarker ELISA Magnetic resonance imaging relapsing remitting CNS central nervous system grey matter white matter interquartile range Expanded Disability Status Scale Multiple sclerosis neurofilament Stress-activated protein kinase primary progressive secondary progressive control group