| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018725 | Experimental Neurology | 2011 | 10 Pages |
Abstract
⺠We test the therapeutic effects of Niaspan in diabetic rats after stroke. ⺠T1DM rats exhibit increased BBB leakage, brain hemorrhage, vascular damage and decreased functional outcome. ⺠Niaspan treatment promoted vascular remodeling and improved functional outcome. ⺠Ang1/Ang2/Tie2 signaling pathways may contribute to diabetes-induced vascular damage. ⺠Targeting Angiopoietins/Tie2 may have beneficial effect in diabetes with stroke.
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Authors
Xinchun Ye, Michael Chopp, Xu Cui, Alex Zacharek, Yisheng Cui, Tao Yan, Amjad Shehadah, Cynthia Roberts, Xinfeng Liu, Mei Lu, Jieli Chen,