| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018760 | Experimental Neurology | 2012 | 7 Pages |
Abstract
⺠The study uses CHOP siRNA approach to reduce cerebral vasospasm after SAH. ⺠CHOP elimination suppressed bim, while it upregulated bcl-2 in the in vascular tissues. ⺠Endothelial apoptosis and narrowing of the basilar artery were reduced with siRNA. ⺠Amelioration of vasospasm was accompanied by reduced neuronal damage in the hemorrhagic brain.
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Authors
Zhaohui He, Robert P. Ostrowski, Xiaochuan Sun, Qingyi Ma, Jiping Tang, John H. Zhang,