Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6018770 | Experimental Neurology | 2012 | 11 Pages |
Abstract
⺠Dopamine D3 receptor dysfunction increases pain reflexes in vivo and reduces their FM modulation in the spinal cord in vitro. ⺠D1 and D2 receptor agonists and the Ca2+-channel ligand, pregabalin, can restore the FM modulation. ⺠Our data suggest a role for the D3 receptor in the modulation of pain-associated spinal cord pathways. ⺠The D3 receptor knockout mouse may serve as a new model for the study of increased nociception.
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Authors
Benjamin E. Keeler, Christine A. Baran, Kori L. Brewer, Stefan Clemens,