Article ID Journal Published Year Pages File Type
6018845 Experimental Neurology 2012 8 Pages PDF
Abstract
►Glyoxalase I protects against damaging effects of advanced glycation end products. ►We examine two strains of mice that naturally express different levels of GLO1. ►Diabetic BALB/cJ mice with low levels develop several classic signs of neuropathy. ►Diabetic BALB/cByJ mice with high levels do not develop signs of neuropathy. ►These mice provide a new tool to explore the role of GLO1 and AGE-related damage.
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