Article ID Journal Published Year Pages File Type
6018846 Experimental Neurology 2012 15 Pages PDF
Abstract
► A significant portion of patients with epilepsy are resistant to medical treatment. ► Understanding mechanisms of resistance is needed for developing more efficacious treatments. ► In epileptic rats, EEG video/monitoring was used to evaluate response to phenobarbital. ► About 50% of the rats were resistant, while other rats responded with significant seizure suppression. ► Several factors that may be relevant for resistance were compared in responders and nonresponders.
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