| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018921 | Experimental Neurology | 2012 | 10 Pages |
Abstract
⺠Epilepsy and Alzheimer's disease are often comorbid conditions. ⺠BACE1 is an enzyme involved in generating β-amyloid, a component of senile plaques. ⺠BACE1 was elevated in chronically epileptic mouse hippocampus. ⺠Increases in GAP-43 and PSA-NCAM colocalized with elevated BACE1. ⺠BACE1 may be involved in pathology-induced axon sprouting.
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Authors
Xiao-Xin Yan, Yan Cai, Xue-Mei Zhang, Xue-Gang Luo, Huaibin Cai, Gregory M. Rose, Peter R. Patrylo,