| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6018936 | Experimental Neurology | 2012 | 9 Pages |
Abstract
⺠Impact of a parkinsonian toxin on developing primate dopamine neurons was studied. ⺠At mid-gestation and in adults, dopamine neurons are sensitive to MPTP. ⺠In the young monkey, dopamine neurons are resistant to MPTP. ⺠Uncoupling protein 2 is upregulated in substantia nigra of young monkeys. ⺠Susceptibility of dopamine neurons to oxidative stress appears to be age-dependent.
Keywords
UCP2GADPHVTAMPTPMPP+ROSSNpcImmunoreactivityParkinson's diseasesubstantia nigrasubstantia nigra pars compactatyrosine hydroxylaseDopamineDevelopmentembryonic daypostnatal dayCSFCerebrospinal fluidventral tegmental areahomovanillic aciduncoupling protein 2Uncoupling proteinHVAglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen species
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Authors
B.A. Morrow, R.H. Roth, D.E. Jr., S. Diano, J.D. Elsworth,