Article ID Journal Published Year Pages File Type
6018951 Experimental Neurology 2012 10 Pages PDF
Abstract
► HECT-type ubiquitin ligases are involved in neuron survival after ischemia. ► Ndfip1, Nedd4-2 and Itch are upregulated in surviving cells. ► Nedd4-1 is not upregulated during ischemia. ► Upregulation of Ndfip1 and Itch occurs separately in different cell types. ► Ndfip1 and Nedd4-2 show biochemical interaction in ischemia.
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Life Sciences Neuroscience Neurology
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Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke
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