Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

Article ID	Journal	Published Year	Pages	File Type
6018962	Experimental Neurology	2012	9 Pages	PDF

Abstract

âº KU-32 is a C-terminal Hsp90 inhibitor that improves physiological indices of DPN. âº Weekly KU-32 therapy significantly increased intra-epidermal nerve fiber density. âº Diabetes decreased and KU-32 improved sensory neuron mitochondrial function. âº Enhanced mitochondrial bioenergetics may contribute to the efficacy of KU-32.

Keywords

FBG SRC MRC SNCV Hsp IENF FCCP STZ DPN MNCV streptozotocin Bioenergetics nerve conduction velocity Sensory nerve conduction velocity motor nerve conduction velocity spare respiratory capacity Respiratory capacity Intraepidermal nerve fiber fasting blood glucose Mitochondria Sensory neurons diabetic peripheral neuropathy Heat shock protein