Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates

Article ID	Journal	Published Year	Pages	File Type
6019040	Experimental Neurology	2012	8 Pages	PDF

Abstract

âº Social stress and depression have many characteristics in common and promote each other. âº Stress and depression adversely affect social relationships, quality of life, and disease risk. âº However, social stress and depression are not the same constructs. âº The behavior and neurobiology of social stress and depression are different. âº Discrimination between stress and depression is crucial in animal models.

Keywords

5-HT1A IGF-1 HDL-C OVX TPC ovariectomized Tph CRH DEX ACTH 5-HT Coronary artery atherosclerosis Social stress Depression insulin-like growth factor-1 Positron emission tomography Body composition Dexamethasone Behavior Serotonin body mass index BMI Heart rate CSF Cerebrospinal fluid Animal models HPA adrenocorticotropic hormone corticotropin-releasing hormone homovanillic acid tryptophan hydroxylase hypothalamic–pituitary–adrenal PET binding potential Progesterone Nonhuman primate HVA high density lipoprotein cholesterol total plasma cholesterol cortisol dopamine receptor D2 serotonin 1A receptor