Article ID Journal Published Year Pages File Type
6019066 Experimental Neurology 2012 9 Pages PDF
Abstract
►Wntless (WLS) mediates Wnt protein secretion, critical for neuronal development. ►Morphine induced a shift of WLS from the cytoplasm to the plasma membrane. ►DAMGO treatment induced a greater distribution of WLS intracellularly. ►Agonist-induced trafficking of WLS in striatum is shown after agonist exposure. ►WLS trafficking may represent a novel target in the treatment of opiate addiction.
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