Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6019083 | Experimental Neurology | 2012 | 10 Pages |
Abstract
⺠Symptoms evoked by hemicerebellectomy are reflected by GAP-43 levels modifications. ⺠GAP-43 mediates retrograde death in pre-cerebellar neurons axotomized by the lesion. ⺠GAP-43 mediates plastic response in not-axotomized pontine and deep cerebellar nuclei. ⺠Plasticity of spared ponto-cerebellar circuit precedes and drives functional recovery. ⺠GAP-43 level in each cerebellar nucleus is related to recovery from specific symptoms.
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Authors
Lorena Burello, Paola De Bartolo, Francesca Gelfo, Francesca Foti, Francesco Angelucci, Laura Petrosini,