Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6019091 | Experimental Neurology | 2012 | 9 Pages |
Abstract
⺠We examined the degradation of the NOTCH3 extracellular domain (N3ECD). ⺠The wild N3ECD was degraded more rapidly than mutant when co-cultured with ligand. ⺠The degradation of mutant N3ECD on the cell surface was disturbed. ⺠The impaired transendocytosis of mutant N3ECD into the ligand cells was assumed. ⺠The mutant N3ECD on the cell surface may contribute to the pathogenesis of CADASIL.
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Authors
Akiko Watanabe-Hosomi, Yoshihisa Watanabe, Masaki Tanaka, Masanori Nakagawa, Toshiki Mizuno,